CREHYTINE™ Patent

The CreHytine™ patent is an advanced form of micronized creatine monohydrate developed by the biotechnology company MCB. Its differentiating value lies in the use of proprietary buffered hydrogel matrix encapsulation technology, designed to address common issues with conventional creatines, such as instability in liquids and stomach discomfort.

Supplement brands that incorporate this raw material (such as Paleobull, Procell, or Longevitas) and the manufacturer highlight the following key points about its patent and benefits:

1. Its Patented Technology (Hydrogel Matrix)

  • Encapsulation and stabilization: The formula physically combines micronized creatine monohydrate with acacia gum (gum arabic) and magnesium (in the form of bisglycinate or malate). This mixture creates a hydrogel-like protective layer that coats each creatine granule.
  • Alkaline pH system: Unlike conventional creatine (which usually has an acidic pH), CreHytine™ features alkaline buffering technology that raises the pH to levels between 9 and 11. This prevents the creatine from rapidly degrading into creatinine upon contact with liquids or stomach acids.

2. Benefits of This Patented Form

  • Maximum solubility: Being 100% water-soluble, it dissolves instantly and avoids the unpleasant gritty texture at the bottom of the glass that characterizes other products.
  • High digestive tolerance: The microencapsulation protects the creatine during the digestive process. This drastically reduces gastrointestinal discomfort, gas, or stomach heaviness experienced by some people with traditional monohydrate.
  • Greater bioavailability: By not degrading in the digestive tract and being absorbed more efficiently, its delivery and accumulation in muscle tissue cells are optimized.

3. Benefits for Athletic Performance and Health

In compliance with EFSA endorsements and scientific evidence, the classic benefits enhanced by its efficient delivery are highlighted:

  • High-intensity performance: It helps increase physical performance and strength during successive sets of short, high-intensity exercises (with a suggested daily dose of 3 grams).
  • Muscle support and fatigue: By being complemented with magnesium and minerals within the same matrix, it helps normal muscle function, electrolyte balance, and reduces tiredness and fatigue.

Technology and Advantages of the Patent

The “buffered hydrogel” technology encapsulates the micronized creatine in an alkaline microenvironment. According to the manufacturer, this:

  • Improves stability and reduces degradation into creatinine in acidic environments (stomach or liquids).
  • Achieves practically total and instant solubility in water (without a gritty texture).
  • Improves digestive tolerance and reduces gastrointestinal discomfort, gas, or heaviness.
  • Can increase bioavailability and delivery to tissues.
  • Includes magnesium in the matrix in some variants, which provides electrolyte and muscle support.

It has obtained the SNQ certification (National Quality Mark of Taiwan) and the Informed Sport certification in the ingredient category (aligned with WADA standards). The hydrogel encapsulation technology is patented.

Important: The specific benefits regarding performance, solubility, and tolerance are based on the manufacturer's claims and the general evidence of creatine monohydrate (more than 700 studies). 

Brain-Level Benefits

Creatine (in general) is key for the phosphocreatine-ATP system in the brain, which needs quick energy. The most studied effects include:

  • Support for working memory, processing speed, and cognitive function, especially in situations of stress, insufficient sleep, or high mental demand.
  • Possible increase in creatine levels in the brain (demonstrated by MRI in some studies).
  • In women, there seems to be greater potential for benefit because they usually have lower endogenous creatine reserves and estrogen influences brain energy metabolism.

A recent trial (CONCRET-MENOPA, 2025/2026) with 36 perimenopausal and menopausal women showed that low doses of soluble forms of creatine (hydrochloride, 750-1500 mg/day for 8 weeks) increased creatine levels in the frontal cortex, improved reaction time, and tended to reduce the intensity of mood swings, with good tolerance. It is not a study specifically with CreHytine, but it supports the interest in more soluble and well-tolerated forms.

Menopause and Perimenopause

During the menopausal transition, the drop in estrogen is associated with:

  • Greater risk of loss of muscle mass and strength.
  • Changes in brain energy metabolism (possible “brain fog,” cognitive fatigue, lower concentration).
  • Sleep and mood disturbances in some women.

Creatine is being investigated in this context because:

  • It helps maintain strength and muscle mass (well-documented classic effect).
  • It can support brain energy metabolism and, according to the mentioned trial, improve cognitive and mood aspects.
  • Some observations point to possible favorable effects on the lipid profile and sleep quality.

CreHytine™, being monohydrate with better solubility and digestive tolerance + magnesium intake, could be more convenient for long-term daily use in women seeking these benefits, although again, specific data on this patent in menopause do not yet exist.

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